Metrics details Abstract Extract: After the infusion of fructose, 0. The mean blood inorganic phosphate Pi levels were significantly less than the mean fasting value after fructose. Blood glucose, lactic acid, and fructose levels were significantly increased after fructose, but serum magnesium levels did not change. In two patients with hereditary fructose intolerance HFI the peak blood uric acid levels were

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Epub Nov Lactobacillus brevis DM ameliorates fructose-induced hyperuricemia through inosine degradation and manipulation of intestinal dysbiosis. Electronic address: vivianmarat Probiotics are powerful weapons to combat metabolic disturbance and intestinal dysbiosis. Previously we isolated a Lactobacillus strain named DM that could reduce the serum uric acid UA level by assimilating purine nucleosides.

The present study aimed to evaluate the effects of DM on high-fructose-induced hyperuricemia and to elucidate the underlying mechanisms. Metabolic parameters, fructose- and UA-related metabolites, and fecal microbiota were investigated. Whole-genome sequencing of strain DM was also conducted. In addition, an inosine hydrolase from DM was heterologously expressed in Escherichia coli, and its inosine-degrading activity was detected.

It could protect against high-fructose-induced liver damage and retard UA accumulation by degrading inosine. The modulation effect of DM on high-fructose-induced intestinal dysbiosis resulted in enhancement of intestinal barrier function and reduction of liver lipopolysaccharide, which was closely correlated with the down-regulation of inflammatory cytokine-stimulated xanthine oxidase expression and activity.

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Fructose-Induced Hyperuricemia Is Associated With a Decreased Renal Uric Acid Excretion in Humans

Corresponding author: Luc Tappy, hc. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. This article has been cited by other articles in PMC. Ingestion of a high-fructose meal increases blood uric acid UA concentration in healthy subjects 1. Furthermore, high-fructose intake over several days is associated with increased fasting UA concentration 1.


Studies on the mechanism of fructose-induced hyperuricemia in man.

Pediatr Res. Fructose-induced hyperuricemia: observations in normal children and in patients with hereditary fructose intolerance and galactosemia. After the infusion of fructose, 0. The mean blood inorganic phosphate Pi levels were significantly less than the mean fasting value after fructose.

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