DOLOPHINE PRESCRIBING INFORMATION PDF

Divide the total daily methadone dose derived from the table above to reflect the intended dosing schedule i. Always round the dose down, if necessary, to the appropriate Dolophine Tablets strength s available. Round down, if necessary, to the appropriate Dolophine Tablets strengths available. Conversion from Parenteral Methadone to Dolophine Tablets: Use a conversion ratio of mg for parenteral to oral methadone e. Titration and Maintenance of Therapy for Pain Individually titrate Dolophine Tablets to a dose that provides adequate analgesia and minimizes adverse reactions. Continually reevaluate patients receiving Dolophine Tablets to assess the maintenance of pain control and the relative incidence of adverse reactions, as well as monitoring for the development of addiction, abuse, or misuse [see Warnings and Precautions 5.

Author:Voodoozragore Nalar
Country:Dominican Republic
Language:English (Spanish)
Genre:Love
Published (Last):7 May 2007
Pages:31
PDF File Size:11.35 Mb
ePub File Size:12.29 Mb
ISBN:201-8-98154-464-1
Downloads:51680
Price:Free* [*Free Regsitration Required]
Uploader:Dougrel



Note: This document contains side effect information about methadone. Some of the dosage forms listed on this page may not apply to the brand name Dolophine.

For the Consumer Applies to methadone : oral solution, oral tablet, oral tablet for suspension Other dosage forms: Warning Oral route Tablet for Suspension Deaths due to too-rapid titration, drug interactions, or cardiac and respiratory side effects have occurred with methadone use for opioid dependence. Respiratory depression is the main hazard associated with methadone administration. QT interval prolongation and serious arrhythmias torsades de pointes have been observed during treatment with methadone.

Only approved hospitals and pharmacies can dispense oral methadone for the treatment of narcotic addiction. Life-Threatening Respiratory Depression Serious, life-threatening, or fatal respiratory depression may occur with use of methadone hydrochloride tablets. The peak respiratory depressant effect of methadone occurs later, and persists longer than the peak analgesic effect, especially during the initial dosing period or following a dose increase. Monitor for respiratory depression, especially during initiation of methadone hydrochloride tablets or following a dose increase.

Proper dosing and titration are essential and methadone hydrochloride should only be prescribed by healthcare professionals who are knowledgeable in the use of methadone for toxification and maintenance treatment of opioid addiction. Accidental Ingestion Accidental ingestion of even one dose of methadone hydrochloride tablets, especially by children, can result in a fatal overdose of methadone.

Life-Threatening QT Prolongation: QT interval prolongation and serious arrhythmia torsades de pointes have occurred during treatment with methadone. Most cases involve patients being treated for pain with large, multiple daily doses of methadone, although cases have been reported in patients receiving doses commonly used for maintenance treatment of opioid addiction. Closely monitor patients with risk factors for development of prolonged QT interval, a history of cardiac conduction abnormalities, and those taking medications affecting cardiac conduction for changes in cardiac rhythm during initiation and titration of methadone hydrochloride tablets Neonatal Opioid Withdrawal Syndrome Neonatal opioid withdrawal syndrome NOWS is an expected and treatable outcome of use of methadone hydrochloride tablets during pregnancy.

NOWS may be life-threatening if not recognized and treated in the neonate. Advise the patient of the risk of NOWS so that appropriate planning for management of the neonate can occur. Cytochrome P InteractionThe concomitant use of methadone hydrochloride tablets with all cytochrome P 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors may result in an increase in methadone plasma concentrations, which could cause potentially fatal respiratory depression.

In addition, discontinuation of concomitantly used cytochrome P 3A4, 2B6, 2C19, or 2C9 inducers may also result in an increase in methadone plasma concentration. Follow patients closely for respiratory depression and sedation, and consider dosage reduction with any changes of concomitant medications that can result in an increase in methadone levels. Risks from Concomitant Use with Benzodiazepines or Other CNS Depressants Concomitant use of opioids with benzodiazepines or other central nervous system CNS depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death.

Reserve concomitant prescribing of methadone and benzodiazepines or other CNS depressants for use in patients for whom alternative treatment options are inadequate. Limit dosages and durations to the minimum required. Follow patients for signs and symptoms of respiratory depression and sedation.

If the patient is visibly sedated, evaluate the cause of sedation, and consider delaying or omitting the daily methadone dose.

Along with its needed effects, methadone the active ingredient contained in Dolophine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking methadone: Incidence not known.

GIORGIO AGAMBEN NUDITIES PDF

Medication Guide

Note: This document contains side effect information about methadone. Some of the dosage forms listed on this page may not apply to the brand name Dolophine. For the Consumer Applies to methadone : oral solution, oral tablet, oral tablet for suspension Other dosage forms: Warning Oral route Tablet for Suspension Deaths due to too-rapid titration, drug interactions, or cardiac and respiratory side effects have occurred with methadone use for opioid dependence. Respiratory depression is the main hazard associated with methadone administration. QT interval prolongation and serious arrhythmias torsades de pointes have been observed during treatment with methadone. Only approved hospitals and pharmacies can dispense oral methadone for the treatment of narcotic addiction.

BEZIELING EN KWALITEIT IN ORGANISATIES PDF

Dolophine Side Effects

Sasar Start these patients on lower doses and titrate slowly while carefully monitoring for signs of respiratory and CNS depression. Infants born to narcotic-addicted women treated with methadone during pregnancy have been found to have decreased fetal growth with reduced birth weight, length, or head circumference. Monitor patients for symptoms of opioid-induced endocrinopathy. Whenever possible, pain management should be colophine with health care providers before any surgery or dental work takes place. Methadone should be reserved for patients in whom alternative treatment options e.

Related Articles